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Chlorpropamide’s plasma half-life may be prolonged by Zyloprimsince Zyloprim and chlorpropamide may compete for excretion in the renal tubuleThe risk of hypoglycemia secondary to this mechanism may be increased if Zyloprim and chlorpropamide are given concomitantly in the presence of renal insufficiency.
Allopurinol is a type of medication called a xanthine oxidase inhibitorIt works by reducing the production of uric acid in the bodyIt comes in the form of an oral tablet.
Liver functionAllopurinol may reduce liver function and can cause liver failureIf you have liver problemsdiscuss with your doctor how this medication may affect your medical conditionhow your medical condition may affect the dosing and effectiveness of this medicationand whether any special monitoring is neededYour doctor may want to test your liver function regularly with blood tests while you are taking this medication.
In transferring a patient from a uricosuric agent to Zyloprimthe dose of the uricosuric agent should be gradually reduced over a period of several weeks and the dose of Zyloprim gradually increased to the required dose needed to maintain a normal serum uric acid level.
Laboratory TestsThe correct dosage and schedule for maintaining the serum uric acid within the normal range is best determined by using the serum uric acid as an index.
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thatis why it is known as zyloprim , while in other countries it continues to be notified when the liquid is cooled forming crystals.